Skip Navigation

JNCI Monographs 2008 2008(39):16-19; doi:10.1093/jncimonographs/lgn017
This Article
Right arrow Full Text
Right arrow Full Text (PDF)
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Add to My Personal Archive
Right arrow Download to citation manager
Right arrow Request Permissions
Google Scholar
Right arrow Articles by Soutoglou, E.
Right arrow Articles by Misteli, T.
PubMed
Right arrow PubMed Citation
Right arrow Articles by Soutoglou, E.
Right arrow Articles by Misteli, T.
Social Bookmarking
Add to CiteULike   Add to Connotea   Add to Del.icio.us  
What's this?

Published by Oxford University Press 2008.

On the Contribution of Spatial Genome Organization to Cancerous Chromosome Translocations

Evi Soutoglou, Tom Misteli

Affiliation of authors: National Cancer Institute, National Institutes of Health, Bethesda, MD

Correspondence to: Tom Misteli, National Cancer Institute, National Institutes of Health, Bethesda, MD 20892 (e-mail: mistelit{at}mail.nih.gov).

The formation of cancer translocations requires the physical interaction of the translocating chromosomes. It has been postulated that the nonrandom spatial organization of the genome within the cell nucleus contributes to determining the outcome of chromosomal translocation. Comparative analysis of the spatial arrangement of translocations partners and their frequency of translocation suggests that translocations occur preferentially among proximally positioned genome regions. This model makes predictions about mechanisms of translocations and the dynamic properties of genome regions in vivo. Elucidating the contribution of spatial genome organization to the formation of chromosome translocations is an integral part of understanding how translocations form in vivo and has provoked the interrogation of several fundamental aspects of genome cell biology, including tissue-specific differences in genome organization, dynamics of genomes in vivo, and the mechanisms that are determining genome organization in vivo.


Add to CiteULike CiteULike   Add to Connotea Connotea   Add to Del.icio.us Del.icio.us    What's this?


This article has been cited by other articles:


Home page
 J Natl Cancer Inst MonogrHome page
C. S. Rabkin and S. Janz
Overview of Mechanisms and Consequences of Chromosomal Translocation
J Natl Cancer Inst Monographs, July 1, 2008; 2008(39): 1 - 1.
[Full Text] [PDF]


Disclaimer:
Please note that abstracts for content published before 1996 were created through digital scanning and may therefore not exactly replicate the text of the original print issues. All efforts have been made to ensure accuracy, but the Publisher will not be held responsible for any remaining inaccuracies. If you require any further clarification, please contact our Customer Services Department.